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The Hallmarks of Cancer

Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57-70.

Weinberg and Hanahan, in 2000[1], proposed six essential capabilities found in tumour cells that encompass the “hallmarks of cancer.”

1. self-sufficiency in growth signals

2. insensitivity to antigrowth signals

3. evasion of apoptosis

4. limitless replicative potential

5. sustained angiogenesis

6. tissue invasion and metastasis

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1. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell. 2000;100(1):57–70.

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